The Discovery Labs has signed a foundational lease with the University of Pennsylvania Gene Therapy Program (GTP), which will use Discovery Labs’ suburban campus for a portion of its expanding research operations focused on the  development of genetic medicines for rare and orphan diseases, as well as acquired and pandemic infectious diseases, such as COVID-19.

The lease with Penn’s Gene Therapy Program—led by James M. Wilson, MD, PhD, director, Gene Therapy Program; Rose H. Weiss professor and director, Orphan Disease Center; and professor of Medicine and Pediatrics, Department of Medicine at the Perelman School of Medicine at the University of Pennsylvania—establishes an anchor tenancy for The Discovery Labs’ new seven-million-square-foot life sciences cluster in Philadelphia’s Cellicon Valley.

“Dr. Wilson and his incredible team at Penn have helped establish Philadelphia as a leader in gene therapies, and we are deeply honored to have the opportunity to work with him and his incredible team of scientists through the expansion of their world-class research and development labs,” said Brian O’Neill, founder and chairman, Discovery Labs. “To welcome Penn’s Gene Therapy Program as the anchor tenant for our planned life sciences cluster here in King of Prussia is strong validation for the incredible life science ecosystem that is emerging in Greater Philadelphia.”

About Discovery Labs’ Facility

The facility expands the Gene Therapy Program’s available space for vector operations, including two dedicated floors for the expanded Penn Vector Core, a full-service viral vector core facility that produces viral-based vectors for gene transfer for researchers both within and outside of Penn. The Penn Vector Core has deep expertise in vector technology for basic research applications that advance understanding of gene function and the development of therapeutic vectors.

Its new space will support discovery research all the way through submission of Investigational New Drug (IND) applications for clinical trials. Additional capabilities will include more capacity for non-clinical proof-of-concept research, large-scale vector production activities; expanded high-throughput research manufacturing for pre-clinical projects; platform development and process optimization; and assay development and qualification, quality control testing, and technical transfer.

“The past few years have been a pivotal time in the development of gene therapies, and our new space at Discovery Labs will propel us even further in charting the future of the field,” Wilson said. “With additional state-of-the-art equipment and increased operational capabilities, we are well-positioned to enhance the design and execution of our innovative, transformative therapies.”

Terms of the Deal

Terms of the deal include a multi-year lease and over 150,000 square feet of lab space encompassing two buildings on Discovery Labs’ one-million-square-foot campus on Swedeland Road in King of Prussia. Penn Medicine joins GSK, WuXi Biologics, and The Center for Breakthrough Medicines (CBM) on the biotech innovation campus.

The Gene Therapy Program will be adjacent to the Discovery Labs’ 700,000-square-foot Innovation Renaissance campus anchored by other leading healthcare companies and organizations such as Thomas Jefferson University Health, Children’s Hospital of Philadelphia, Amerisource Bergen/World Courier, and Tosoh Biosciences and is just up the road from the recently acquired 660,000 square foot Philadelphia Inquirer printing plant that will be converted into life science research and manufacturing facilities.