PharmAbcine Inc. has entered into a strategic partnership with Samsung Biologics for the development and manufacturing of PMC-403 pipeline, the next generation therapeutic antibody candidate to treat neovascular disorders. Samsung will provide the full scope of its CDO services from cell line development, process development, cGMP clinical manufacturing to IND filing support.

PharmAbcine’s lead molecule, Olinvacimab, is in phase II clinical trials for a combination therapy to treat cancer with MSD's Keytruda.

PMC-403 is a novel agonistic antibody that binds to the human Tie2 receptor. PharmAbcine is developing PMC-403 as a therapeutic drug for both non ocular and ocular pathological vessel related diseases. The company expects PMC-403 to enter a global ophthalmological clinical trial in 2022.

More recently, PharmAbcine signed a material cooperative research collaboration agreement with the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), in which NIAID will assess the efficacy of PMC-403 to treat Systemic Capillary Leak Syndrome (SCLS or Clarkson Disease). 

"This marks a significant turning point for PharmAbcine because we are finally taking the actual steps to expand the indications of our angiogenesis assets beyond oncology," said Dr. Jin-San Yoo, CEO of PharmAbcine. "We expect to use PMC-403 molecules produced under this contract in not only preclinical research collaboration with NIAID for SCLS therapeutics but also our own R&D efforts to treat various vascular diseases."