Gemini Bioproducts LLC, a supplier of cell culture solutions and a portfolio company of BelHealth Investment Partners, has launched the Moxi V for precision cell analysis.

The Moxi V utilizes the Coulter Principle to precisely measure cell volumetric sizes, enabling researchers to easily track detailed size profiles in their cell samples. This exact cell sizing capability of the Moxi V is an essential requirement for the monitoring of T-Cell activation curves for CAR-T cell research in immunotherapy and for the mapping of size distributions for both cell types and debris in complex single cell sequencing preparations.

Ted Ayliffe, Gemini Bio’s chief technology officer stated, “We are excited to introduce the Moxi V as a technology platform that successfully merges two crucial, gold-standards in cell analysis: Coulter Principle-based cell counts and sizing with flow cytometry-based cell viability measurements. In combining these capabilities into a single system that is a fraction of the cost of the individual high-end instruments, the Moxi V addresses critical unmet needs in immunotherapy/CAR-T research, single cell sequencing QC, and all research applications in which cell count, size, and viability accuracy are essential.”

According to the company, the Moxi V utilizes a patented thin-film microfluidic flow cell technology to eliminate the hassles associated with the operation, cleaning and disinfecting of other systems. Also, a simple touchscreen interface and auto-gating algorithm enables users to implement the technology without the need for extensive training.

The system comes equipped with a 532nm laser and a 561nm/LP detection channel for robust cell viability analysis. Propidium Iodide (PI)-stained dead cells measure 50-100 times brighter fluorescence on the system than do live cells, removing the ambiguity associated with traditional Trypan Blue viability assessments. Gemini Bio says that each test enables users to analyze up to 23,000 cells in a matter of a few seconds ensuring the highest level of precision and statistical robustness.