After experiencing mixed results in defense of its storied Johnson's Baby Powder brand, Johnson & Johnson faces its biggest legal test yet for the product.

Opening statements begin Wednesday in a trial consolidating the claims of 22 plaintiffs—six of whom are deceased—who say their routine use led to ovarian cancer. J&J denies the claims.

The women say J&J has known about the alleged link to cancer for decades, and that the company has long known about potential asbestos contamination in its product. Plaintiffs also say J&J worked with lobbyists to suppress evidence of a link to cancer rather than warn consumers. The trial is expected to run through mid-July. 

A J&J representative didn't immediately respond to a request for comment on the trial.

It's the latest talc trial to kick off in St. Louis, where J&J has suffered some previous defeats in cases over its storied brand. Juries in the city have already ordered the company to pay verdicts of $55 million, $70 million and $110 million, and J&J has pledged to appeal in each instance. 

After other losses—one in St. Louis—Johnson & Johnson has had some success in appeals. The company has won reversals of a $417 million Los Angeles talc verdict and another $72 million verdict handed down by a St. Louis jury. The company has also won ovarian cancer talc cases in New Jersey and St. Louis. 

Recently, some plaintiffs have taken claims of a link between the product and mesothelioma to trial, with some success. This year, plaintiffs in New Jersey and Los Angeles won verdicts of $117 million and $25.75 million, respectively, and J&J said it will appeal. The company previously won a mesothelioma lawsuit in Los Angeles, and another late last month ended in a mistrial in South Carolina. 

As of J&J's most recent quarterly filing with the SEC, the company faces about 9,100 lawsuits alleging harm from talc powder use.

Register as Visitor to CPhI China 2018!