1, drug synthesis: 2-pyrrolidone is an important organic synthesis intermediate, can be used to manufacture N-vinyl pyrrolidone (NVP), NVP and then polymerized to obtain polyvinylpyrrolidone (PVP). PVP has excellent solubility, low toxicity, film forming, complexation, surface activity and chemical stability, and is widely used in the field of medicine. By modifying and functionalizing the structure of 2-pyrrolidone, many compounds with a variety of biological activities can be prepared, such as the psychotropic drug piracetam.
2, anti-HIV drugs: a series of phenyl-substituted 2-pyrrolidone compounds have been designed and synthesized, and their anti-HIV activity has been investigated, in order to find a class of effective reverse transcriptase inhibitors.
3. Potassium channel blockers: Derivatives of 2-pyrrolidone can be used as potassium channel blockers and are particularly suitable as antiarrhythmic active ingredients, especially for the treatment and prevention of atrial arrhythmias, such as atrial fibrillation (AF) or atrial flutter.